Ruba Deeb

Ruba Deeb, Ph.D.

Director of Biomedical Research Development, Associate Professor of Biomedical Engineering & Technology Management

Charles A. Dana Hall – Office 215
(203) 576-4399

Over the last 20 years, Dr. Deeb has worked with a diverse team of investigators on unraveling the pathophysiology of lung and cardio-metabolic diseases. During that period, she was an assistant Professor of Pathology and of Genetic Medicine at the Weill Medical College of Cornell University. Her research has focused on mechanisms that regulate inflammatory processes as they relate to metabolic networks with the goal to discover disease biomarkers, monitor disease progression, and measure the efficacy of therapeutic intervention. The nature of this work involved engagement with powerful bioanalytical techniques and bioinformatics tools for high throughput measurements of biological molecules that enabled the generation of new concepts concerning the complex interactions between inflammatory mediators in human blood vessels and airways during oxidative stress. Dr. Deeb joined the University of Bridgeport (UB) community in 2015 where she currently serves as the Director of Biomedical Research Development and the Director of the Collaborative Biomedical Research Center (CBRC). She is also a Research Associate Professor of Biomedical Engineering. At UB, Dr. Deeb is engaged in two research projects. For the first project, she collaborates with colleagues at Weill Cornell Medical College to identify and characterize the role of soluble bioactive mediators in cellular repair processes that allow for the regeneration of the human airway following exposure to the high burden of oxidants and toxins in cigarette smoke. The goal of this project is to identify molecular alterations that originate in lung cells of healthy smokers before progression and manifestation of lung disease. For the second project, Dr. Deeb collaborates with colleagues at UB and at Yale University to understand how to minimize permanent organ tissue damage following periods of hypoxia and oxidative stress from lung collapse or lung disease. Most recently, Dr. Deeb has identified a biochemical pathway that serves to repair oxidative damage of a critical biomolecule in cardiomyocytes (SERCA2a). SERCA2a is critical for calcium cycling and cardiac muscle contraction and relaxation. Together with collaborators, Dr. Deeb’s research team will translate current findings into a clinical setting to elucidate mechanisms of tissue recovery following oxidative hypoxic injury from lung collapse

 

Education:
Postdoctoral Fellowship, Department of Pathology, Weill Medical College of Cornell University, NY, 1999.
Postdoctoral Fellowship, Department of Biochemistry, Weill Medical College of Cornell University, NY, 1998.
Ph.D., Biochemistry and Environmental Sciences and Resources, Portland State University, OR, 1993.
B.Sc., Chemistry, Walla Walla College, WA, 1988

 

Courses Taught:
TMPD 702-6T1 Exploration in Research Methodologies

 

Publications:
For a comprehensive research profile, refer to: https://www.researchgate.net/profile/Ruba_Deeb/publications

Upmacis, R.K., Shen, H., Benguigui, L.E.S., Lamon, B.D., Deeb, R.S., Hajjar, K.A. and Hajjar, D.P.: Inducible Nitric Oxide Synthase Provides Protection Against Injury-Induced Thrombosis in Female Mice, American Journal of Physiology: Heart and Circulatory Physiology, 2011; 301:H617-24.

Deeb, R.S., Nuriel, T., Cheung, C., Summers, B.D., Lamon, B.D., Gross, S.S., and Hajjar, D.P.: Characterization of a Cellular Denitrase Activity that Reverses Nitration of Cyclooxygenase, American Journal of Physiology: Heart and Circulatory Physiology, 2013; 305:H687-98.

Chen, Q., Deeb, R.S., Ma, Y., Staudt, M., Crystal, R.G., and Gross, S.S.: Serum Metabolite Biomarkers Discriminate Healthy Smokers from COPD Smokers, PLOS One, 2015, 10(12):e0143937.

Deeb, R.S., Walters, M.S., Strulovici-Barel, Y., Chen, Q., Gross, S.S., and Crystal, R.G.: Smoking-associated Disordering of the Airway Basal Stem/progenitor Cell Metobotype, American Journal of Respiratory Cell and Molecular Biology, 2016: 54: 231-241.

Strulovici-Barel Y., Shaykhiev R., Salit J., Deeb R.S., Krause A., Kaner R.J., Vincent T.L., Agosto-Perez F., Wang G., Hollmann C., Shanmugam V., Almulla A.M., Sattar H., Mahmoud M., Mezey J.G., Gross S.S., Staudt M.R., Walters M.S, Crystal R.G.: Pulmonary Abnormalities in Young Light-use Water-pipe (Hookah) Smokers: American Journal of Respiratory and Critical Care Medicine, 2016:194:587-95.

Deeb, R.S. and Hajjar, D.P.: Repair Mechanisms in Oxidant-Driven Chronic Inflammatory Disease: American Journal of Pathology, 2016; 186:1736-1749.