Director of Biomedical Research Development,Research Associate Professor of Biomedical Engineering,Liaison for Dual Credit Programming for the School of Engineering and School of Arts and Sciences
Postdoctoral Fellowship, Department of Pathology, Weill Medical College of Cornell University, NY, 1999.
Postdoctoral Fellowship, Department of Biochemistry, Weill Medical College of Cornell University, NY, 1998.
Ph.D., Biochemistry and Environmental Sciences and Resources, Portland State University, OR, 1993.
B.Sc., Chemistry, Walla Walla College, WA, 1988
Office Location: Charles A. Dana Hall – Office 215
Telephone: (203) 576-4399
Over the last 20 years, Dr. Deeb has worked with a diverse team of investigators on unraveling the pathophysiology of lung and cardio-metabolic diseases. During that period, she was an assistant Professor of Pathology and of Genetic Medicine at the Weill Medical College of Cornell University. Her research has focused on mechanisms that regulate inflammatory processes as they relate to metabolic networks with the goal to discover disease biomarkers, monitor disease progression, and measure the efficacy of therapeutic intervention. The nature of this work involved engagement with powerful bioanalytical techniques and bioinformatics tools for high throughput measurements of biological molecules that enabled the generation of new concepts concerning the complex interactions between inflammatory mediators in human blood vessels and airways during oxidative stress. Dr. Deeb joined the University of Bridgeport (UB) community in 2015 where she currently serves as the Director of Biomedical Research Development and the Director of the Collaborative Biomedical Research Center (CBRC). She is also a Research Associate Professor of Biomedical Engineering. At UB, Dr. Deeb is engaged in two research projects. For the first project, she collaborates with colleagues at Weill Cornell Medical College to identify and characterize the role of soluble bioactive mediators in cellular repair processes that allow for the regeneration of the human airway following exposure to the high burden of oxidants and toxins in cigarette smoke. The goal of this project is to identify molecular alterations that originate in lung cells of healthy smokers before progression and manifestation of lung disease. For the second project, Dr. Deeb collaborates with colleagues at UB and at Yale University to understand how to minimize permanent organ tissue damage following periods of hypoxia and oxidative stress from lung collapse or lung disease. Most recently, Dr. Deeb has identified a biochemical pathway that serves to repair oxidative damage of a critical biomolecule in cardiomyocytes (SERCA2a). SERCA2a is critical for calcium cycling and cardiac muscle contraction and relaxation. Together with collaborators, Dr. Deeb’s research team will translate current findings into a clinical setting to elucidate mechanisms of tissue recovery following oxidative hypoxic injury from lung collapse
TMPD 702-6T1 Exploration in Research Methodologies
The discovery of novel therapeutic targets (biomarkers) and repair mechanisms in acute lung injury via multiplex identification and metabolic profiling of
clinical samples in humans.
Characterization of the biological role of the soluble active mediators nitric oxide and prostaglandins in the human airway using cellular models.
Understanding the molecular basis of chronic inflammation in cardio-metabolic, vascular, and lung diseases.
Community Service & Outreach
Institutional Review Board (University of Bridgeport)
Faculty Research Day (University of Bridgeport)
Advisory Board (Bridgeport Regional Aquaculture Technology and Education Center)
Engineering Advisory Committee (Stratford Public Schools)
School Governance Counsel (Fairchild Wheeler Campus)
Dual Credit Programming for the School of Engineering and the School of Arts and Sciences (University of Bridgeport).
For a comprehensive research profile, refer to: https://www.researchgate.net/profile/Ruba_Deeb/publications
Upmacis, R.K., Shen, H., Benguigui, L.E.S., Lamon, B.D., Deeb, R.S., Hajjar, K.A. and Hajjar, D.P.: Inducible Nitric Oxide Synthase Provides Protection Against Injury-Induced Thrombosis in Female Mice, American Journal of Physiology: Heart and Circulatory Physiology, 2011; 301:H617-24.
Deeb, R.S., Nuriel, T., Cheung, C., Summers, B.D., Lamon, B.D., Gross, S.S., and Hajjar, D.P.: Characterization of a Cellular Denitrase Activity that Reverses Nitration of Cyclooxygenase, American Journal of Physiology: Heart and Circulatory Physiology, 2013; 305:H687-98.
Chen, Q., Deeb, R.S., Ma, Y., Staudt, M., Crystal, R.G., and Gross, S.S.: Serum Metabolite Biomarkers Discriminate Healthy Smokers from COPD Smokers, PLOS One, 2015, 10(12):e0143937.
Deeb, R.S., Walters, M.S., Strulovici-Barel, Y., Chen, Q., Gross, S.S., and Crystal, R.G.: Smoking-associated Disordering of the Airway Basal Stem/progenitor Cell Metobotype, American Journal of Respiratory Cell and Molecular Biology, 2016: 54: 231-241.
Strulovici-Barel Y., Shaykhiev R., Salit J., Deeb R.S., Krause A., Kaner R.J., Vincent T.L., Agosto-Perez F., Wang G., Hollmann C., Shanmugam V., Almulla A.M., Sattar H., Mahmoud M., Mezey J.G., Gross S.S., Staudt M.R., Walters M.S, Crystal R.G.: Pulmonary Abnormalities in Young Light-use Water-pipe (Hookah) Smokers: American Journal of Respiratory and Critical Care Medicine, 2016:194:587-95.
Deeb, R.S. and Hajjar, D.P.: Repair Mechanisms in Oxidant-Driven Chronic Inflammatory Disease: American Journal of Pathology, 2016; 186:1736-1749.
American Heart Association Heritage Affiliate Grant-In-Aid,
Proposal Title: Role of Neuronal Nitric Oxide Synthase in Proneurotrophin Mediated Smooth Muscle Cell Apoptosis in Vascular Injury(2007-2010)
The Charles A. Frueauff Foundation Award, The Charles A. Frueauff Foundation Award, Principal Investigator
Proposal Title: The Role of Oxidative Stress in Vascular Injury(2008-2009)
National Institutes of Health (NHLBI)Project InvestigatorProposal Title: COPD Metabolome, Smoking Oxidants and Aberrant Ciliated Cell Function(2011-2014)
National Institutes of Health (NHLBI)Project Investigator
Proposal Title: HIV+ Alveolar Macrophage Oxidant-mediated Apoptosis of Pulmonary Capillary Endothelium.(2013-2015)
National Institutes of Health (NINDS)Project Investigator
Proposal Title: Spatial Mapping of AAVrh.10CLN2 Therapeutic Efficacy in Late Infantile Neuronal Ceroid Lipofuscinosis Using Advanced Magnetic Resonance Imaging Techniques and Cerebrospinal Fluid Metabolite Concentrations.(2013-2015)
Department of Education (Federal award)Sub-recipient Principal Investigator/ Director of subcontract
Project Title: Bridgeport City School District’s Magnet Schools Project (2013-2016);Develop courses for the Fairchild Wheeler Aerospace/Hydrospace/Biotechnology School; Develop a Pharmaceutical track; Develop and outfit the “Mechatronic” and “Biotech” labs.(2015-2016)
National Institutes of Health (BRAD)Principal Investigator
Project Title: Enhancing Research Administration at an Emerging Research Institution in Urban Southwest Connecticut.(2016-2021)
NASA Connecticut Space Grant Consortium Principal Investigator
Project Title: UB SSEP Mission 12 STEM Educational Research Project.(2017)
National Center for Earth and Space Science Education (NCESSE)SSEP Community Program Director
Project Title: University of Bridgeport Student Spaceflight Experiments Program (SSEP): Mission 12 to the International Space Station(2016-2018)