Assistant Professor of Biomedical Engineering
Ph.D., Engineering Sciences and Innovation Program Fellow, Thayer School of Engineering, Dartmouth College, 2013
M.Sc., Engineering Management, Thayer School of Engineering, Dartmouth College, 2008
B.Sc., Biomedical Engineering with Emphasis on Materials, Thayer School of Engineering, Dartmouth College, 2007
Office Location: Engineering – Technology Bldg – Office 156
Telephone: (203) 576-4100
Postdoctoral Researcher (2013-2016), Geisel School of Medicine, Dartmouth College, Hanover, NH.
Director of Dartmouth Emerging Engineers (2014-2016), Thayer School of Engineering, Dartmouth College, Hanover, NH.
Ph.D. in Engineering Sciences (2013) and Ph.D. Innovation Program Fellow (2010-2013). Thayer School of Engineering, Dartmouth College, Hanover, NH.
Master of Engineering Management (2008). Thayer School of Engineering, Dartmouth College, Hanover, NH.
Bachelor of Engineering in Biomedical Engineering with Emphasis on Materials (2007), Thayer School of Engineering, Dartmouth College, Hanover, NH.
Bachelor of Arts in Engineering Sciences (2006), Thayer School of Engineering, Dartmouth College, Hanover, NH.
I joined the University of Bridgeport (UB) in the fall of 2016, following my postdoctoral work at the Geisel School of Medicine at Dartmouth College, where I studied the cytotoxicity of hyperthermia induced with iron oxide magnetic nanoparticles and alternating magnetic fields. I completed my doctoral work at the Thayer School of Engineering at Dartmouth College. I was also a Master of Engineering Management (MEM) student and a PhD Innovation Fellow, which enabled me to gain experience relating to intellectual property and the commercialization/clinical adaptation of technology.
The research laboratory in which I completed my PhD and postdoctoral research, was part of the Dartmouth Center of Cancer Nanotechnology Excellence (DCCNE). The DCCNE, funded by the NCI through a Center of Cancer Nanotechnology Excellence (CCNE) grant, sought to bring a magnetic nanoparticle-based cancer therapeutic into the clinic. This large and multi-disciplinary effort required expertise in material science, protein engineering, immunology, and medical imaging. In this environment, I was able to develop my research interests which include nanoparticle-cancer therapeutics, medical devices, cancer biology, immunology, biomaterials and the development of meaningful biologic models and experimental prototypes.
My research efforts at UB have built off this prior experience and motivated me to work towards a better understanding of the interaction between nanomaterials, ionizing radiation and hyperthermia. It has been shown that ionizing radiation, combined with hyperthermia, can result in a greater therapeutic ratio in the treatment of cancer than radiation or hyperthermia alone. Recent work has also shown that magnetic nanoparticles (MNP) may have potential as radiation sensitizers. When MNP are exposed to an alternating magnetic field (AMF) a localized hyperthermia can be induced. Hence, the presence of MNP within the tumor may have two independent, but complementary modalities of therapeutic enhancement. Despite this potential, whether or not there are significant benefits or differences that exist as a result of the intracellular uptake of MNP remains an unresolved question in the field. The current efforts of my lab are aimed at a better understanding of the mechanism of cellular uptake of MNP, why some cells within a population take up the MNP more readily than others, and how this affects the cytotoxicity of the therapy. Additional research areas include development of diagnostic sensors for the detection of diseases, which would be both affordable and appropriate for use in remote regions, as well as sensors for children with severe allergies.
Magneto-Bioengineering (BMEG 573)
Tissue Engineering (BMEG 580)
Cancer and Engineering (BMEG 577)
Biomedical Imaging (BMEG 576)
I enjoy collaboration and hope to continue to work in the field of medical devices with scientists from different areas of expertise. The role I played within the Surgical Research Labs has exposed me to many areas of research, including nanotechnology, immunology and medical device design. I have a strong background in the development of meaningful biologic models (in vitro, ex vivo and in vivo) and experimental prototypes which are necessary for translation into the clinic. I have a unique perspective as a result of my MEM training, Innovation Fellowship and my work in industry, as well as my experience in developing a clinical trial. I am enjoy working with students to develop solutions using my training and experience in the multidisciplinary fields of business, medicine and engineering.
Petryk AA, et al., Iron oxide nanoparticle enhancement of ionizing radiation cancer therapy. Invited manuscript Int J Hyperthermia. Submitted for publication.
Zhang J, Ring HL, Idiyatullin D, Petryk AA, Reeves R, Hoopes PJ, Garwood G, Assessment of Iron Oxide Nanoparticles in Murine Tumors Following Intra-tumor and Systemic Delivery using SWIFT MRI. In preparation.
Hoopes PJ, Moodie KL, Petryk AA, et al., “Hypo-fractionated radiation, magnetic nanoparticle hyperthermia and a viral immunotherapy treatment of spontaneous canine cancer.” SPIE BiOS. International Society for Optics and Photonics, 2017.
Pearce JA, Petryk AA, Hoopes PJ, Numerical Model Study of In Vivo Magnetic Nanoparticle Tumor Heating. IEEE Transactions on Biomedical Engineering. IEEE Early Access Articles.
Stigliano RV, Shubitidze F, Petryk JD, Shoshiashvili L, Petryk AA, Hoopes PJ, Mitigation of eddy current heating during magnetic nanoparticle hyperthermia therapy. Int J Hyperthermia. 2016;32(7):735.
Petryk AA, et al., Similarities and differences in ablative and non-ablative iron oxide nanoparticle hyperthermia cancer treatment. Proc of SPIE. 2015;9326:93260K.
Petryk AA, et al., Magnetic nanoparticle hyperthermia cancer treatment efficacy dependence on cellular and tissue level particle concentration and particle heating properties. Proc of SPIE. 2015;9326:93260L.
Baker I, Fiering SN, Griswold KE, Hoopes PJ, Kekalo K, Ndong C, Paulsen K, Petryk AA, et al., The Dartmouth center for cancer nanotechnology excellence: magnetic hyperthermia. 2015; 10(11):1685.
Hoopes PJ, Petryk AA, et al., Utility and translatability of mathematical modeling, cell culture and small and large animal models in magnetic nanoparticle hyperthermia cancer treatment research. Proc of SPIE. 2015;9326:932604.
Kastner EJ, Reeves RA, Petryk JD, Petryk AA, et al., Alternating magnetic field optimization for IONP hyperthermia cancer treatment. Proc of SPIE. 2015;9326:93260M.
Mazur CM, Strawbridge RR, Petryk AA, et al., Effect of radiation energy and intracellular iron dose on iron oxide nanoparticle enhancements of radiation cytotoxicity. Proc of SPIE. 2015;9326: 93260P.
Misra A, Petryk AA and Hoopes PJ, Macroscopic and microscopic biodistribution of intravenously administered iron oxide nanoparticles. Proc of SPIE. 2015;9326:93260N.
Reeves R, Petryk AA, et al., SWIFT-MRI imaging and quantitative assessment of IONPs in murine tumors following intra-tumor and systemic delivery. Proc of SPIE. 2015;9326:93260Q.
Shubitidze F, Kekalo K, Stigliano R, Petryk AA, et al., Magnetic nanoparticles with high specific absorption rate of electromagnetic energy at low field strength for hyperthermia therapy. Journal of applied physics 2015; 117(9):094302. See erratum: Journal of applied physics 2015; 118(17):17990.
Pearce JA, Petryk AA, Hoopes PJ, FEM numerical analysis of magnetic nanoparticle tumor heating experiments. Engineering in Medicine and Biology Society (EMBC), 2014 36th Annual International Conference of the IEEE. 2014;5312.
Chen EY, Samkoe KS, Hodge S, Tai K, Hou H, Petryk AA, et al., Modulation of Hypoxia by Magnetic Nanoparticle Hyperthermia to Augment Therapeutic Index. In Oxygen Transport to Tissue XXXVI (pp. 87-95). Springer, New York. 2014. PMID: 24729219.
Petryk AA, et al., Comparison of magnetic nanoparticle and microwave hyperthermia cancer treatment methodology and treatment effect in a rodent breast cancer model. Int J Hyperthermia. 2013; 29(8):819. PMID: 24219799.
Petryk AA, et al., Magnetic nanoparticle hyperthermia enhancement of cisplatin chemotherapy cancer treatment. Int J Hyperthermia. 2013; 29(8):845. PMID: 24144336.
Petryk AA, et al., Improved delivery of magnetic nanoparticles with chemotherapy cancer treatment. Proc SPIE. 2013;8584:85840H. PMID: 25301996.
Hoopes PJ, Petryk AA et al., Imaging and modification of the tumor vascular barrier for improvement in magnetic nanoparticle uptake and hyperthermia treatment efficacy. Proc of SPIE. 2013;8584:858403. PMID: 25285190.
Stigliano RV, Shubitidze F, Petryk AA, et al., Magnetic nanoparticle hyperthermia: Predictive model for temperature distribution. Proc of SPIE. 2013;8584:85410. PMID: 25301993.
Cunkelman BP, Chen EY, Petryk AA, et al., Development of a biodegradable iron oxide nanoparticle gel for tumor bed therapy. Proc of SPIE. 2013;8584:858411. PMID: 25346584.
Society of Thermal Medicine New Investigator Award (2015). Awarded funding for travel and speaking opportunity at the Society of Thermal Medicine’s Annual Meeting following review of presentation abstract.
Thayer School of Engineering Ph.D. Innovation Program (2010-2013). Awarded fellowship following presentation of research/business plan.
NIH R21 HD087828-01 (Wegst) Spring 2016
A Novel Nanotherapeutic Device for Effective Non-Surgical Female Sterilization
The goal of this grant is to develop a nanomaterial-based, permanent birth control method for women.
Role: Postdoctoral Researcher
Norris Cotton Cancer Center Prouty Pilot Grant (Hoopes and Fiering) 2015-2016
The goal of this pilot grant is to explore the mechanism and potential efficacy of combining a proven immune stimulant and a novel iron oxide nanotechnology. This includes radiation sensitization and hyperthermia.
Role: Postdoctoral Researcher
Munck-Pfefferkorn Award, Geisel School of Medicine (Hoopes and Fiering) 2015-2016
The goal of this grant is to develop a new strategy, utilizing iron oxide nanoparticles, radiation therapy and one of two vaccines that have been proven to stimulate immune systems to fight tumor for treating human melanoma. This study utilizes spontaneous oral melanoma tumors in companion dogs. Role: Postdoctoral Researcher
NIH U54 CA151662-01 (Baker) 2010-2015
Dartmouth Center for Nanotechnology Excellence
Multi-project, multi-department nanotechnology center grant focused on the use of antibody and non-antibody targeted magnetic nanoparticles/AMF for the treatment of breast and ovarian cancer. Role: Graduate Student